Phytochemical and Pharmaco-Toxicological Assessment of Hydro Ethanolic Extract of Taverniera aegyptiaca Boiss

Taverniera aegyptiaca Boiss is a wild plant is grown at the Red Sea coast, Egypt. Traditional uses of this species drive us to evaluate the phytochemical and pharmaco-toxicological aspects of the hydro ethanolic extract of the aerial parts of T. aegyptiaca. Phytochemical screening revealed the presence of various bioactive secondary metabolites as flavonoids, terpenes, glycosides, saponins and sterols compounds which might be responsible for their medicinal attributes. Alkaloids and tannins were not detected. The safety of ethanolic extract of T. aegyptiaca is evidenced by the high LD50 value of the extract (>5g/kg). In addition, there wasn’t significant modification in the general behavior of the animals and deaths after 72 hours post-administration. Oral administration of 500 mg kg hydro ethanolic extract of T. aegyptiaca, significantly inhibited the nociception to acetic acid-induced writhes and increases in the latency to response of tail to thermal stimulation. Furthermore, pretreatment of rats with T. aegyptiaca extract reduced the ulcer index and produced protection in ethanol induced ulceration model. The extract induced all pharmacological effects in a dose dependent manner. These findings suggested that T. aegyptiaca can be used as a promising source of new antinociceptive anti-inflammatory and anti-